Bruce Conklin, MD

Gladstone Institutes | University of California, San Francisco
San Francisco, California

Dr. Bruce Conklin is a Senior Investigator at The Gladstone Institutes and a Professor at the University of California, San Francisco. The Conklin Lab focuses on CRISPR technology with an emphasis on motor neuron diseases, such as dominant forms of CMT. Decoding human genetic disease allows Dr. Conklin to develop models of the pathology that can be directly tested with gene correction. Dominant mutations are particularly promising therapeutic targets since they are resistant to traditional therapies, yet precise excision of disease-causing alleles could provide a cure. Developing CRISPR genome surgery in human neurons provides a path to devise improved cellular models as well as human therapies.