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CMTA-STAR Animal Model Research Projects

CMTA Funds Preclinical Work on Modulating Unfolded Protein Response in CMT1B Mice

CMTA has funded a preclinical study exploring whether modulating the unfolded protein response (UPR) can address disease mechanisms in CMT1B. The project will evaluate activation of the ATF6 pathway in CMT1B mouse models to determine whether this approach can reduce cellular stress linked to myelin dysfunction and inform future therapeutic development.