News

The Charcot-Marie-Tooth Association (CMTA) announced the results of a review of its long-running list of medications known or suspected of being toxic to the peripheral nervous system. With two exceptions for anticancer drugs, the reviewers concluded that the vast majority ...

Scientists at the UCL Queen Square Institute of Neurology in London have identified a new potential therapeutic strategy for CMT type 2D (CMT2D) that may be more broadly effective for treating neuropathy. CMT2D is caused by mutations in the GARS1 ...

CMT is a genetic disease caused by distinct changes in the DNA of a patient and these are typically transmitted in families. Although over 100 different genes, each causing a CMT subtype, have already been identified, more than 50% of ...

In people with CMT1X cell-to-cell communication within the peripheral nervous system is affected, leading to a breakdown in nerve signals resulting in a progressive muscular atrophy (wasting or loss of muscle tissue), weakness, and loss of sensation in the limbs. ...

CMT2E is caused by dominant or recessive mutations in the Nefl gene which codes for the neurofilament protein L protein (NFL). This proposal takes advantage of mouse models of dominant and recessive CMT2E, one a heterozygous “knockin” of the N98S ...