Page 28 - Fall 2020 CMTA Report

Non-Profit Org.
U.S. Postage Paid
Tiffin, OH
Permit #52
CMT PATIENT The Charcot-Marie-Tooth Association
MEDICATION ALERT: P.O. Box 105
Glenolden, PA 19036
Definite high risk 1-800-606-CMTA (2682) FAX (610) 499-9267
(including asymptomatic CMT): www.cmtausa.org
Taxols (paclitaxel, docetaxel,
cabazitaxel)
Vinca alkaloids (Vincristine)
Moderate to significant risk:
Amiodarone (Cordarone)
Arsenic Trioxide (Trisenox)
Bortezomib (Velcade)
Brentuximab Vedotin (Adcetris)
Cetuximab (Erbitux)
Cisplatin and Oxaliplatin
Colchicine (extended use)
Dapsone
Didanosine (ddI, Videx)
Dichloroacetate
Disulfiram (Antabuse)
Eribulin (Halaven)
Fluoroquinolones
Gold salts
Ipilimumab (Yervoy)
Ixabepilone (Ixempra)
Lefluonamide (Arava) W H AT I S C M T ?
Lenalidomide (Revlimid)
Metronidazole/Misonidazole
(extended use)
Nitrofurantoin (Macrodantin,
Furadantin, Macrobid)
Nitrous oxide (inhalation abuse) s More than 3 million people worldwide have CMT, which is one of the most
Nivolumab (Opdivo) commonly inherited nerve disorders and affects the motor and sensory nerves.
Pembrolizumab (Keytruda)
Perhexiline (not used in US)
Pomalidomide (Pomalyst) s CMT is slowly progressive, causing the loss of muscle function and/or sensation
Pyridoxine (mega dose of
Vitamin B 6) in the lower legs and feet, as well as hands and arms.
Stavudine (d4T, Zerit)
Suramin
Thalidomide s Men and women in all ethnic groups may be affected by CMT.
Zalcitabine (ddC, Hivid)
CMT is genetic, but it can also develop as a new, spontaneous mutation.
Uncertain or minor risk: s
5-Fluouracil
Adriamycin s CMT can vary greatly in severity, even within the same family.
Almitrine (not in US)
Chloroquine
Cytarabine (high dose) s CMT causes structural deformities such as high-arched or very flat feet, hammertoes,
Ethambutol
Etoposide (VP-16) hand contractures, scoliosis (spinal curvature) and kyphosis (rounded back).
Gemcitabine
Griseofulvin CMT can also cause foot drop, poor balance, cold extremities, cramps, nerve,
Hexamethylmelamine s
Hydralazine muscle and joint pain, altered reflexes, fatigue, tremor, sleep apnea, hearing loss
Ifosfamide
Infliximab and breathing difficulties.
Isoniazid (INH)
Lansoprazole (Prevacid) ?
Mefloquine s CMT rarely affects life expectancy.
Omeprazole (Prilosec)
Penicillamine Some medications are neurotoxic and pose a high risk to people with CMT, notably
Phenytoin (Dilantin) s
Podophyllin resin Vincristine and Taxols. See full list (at left) of medications that may pose a risk.
Sertraline (Zoloft)
Statins
Tacrolimus (FK506, Prograf) s More than 100 different genetic causes of CMT have been identified.
Zimeldine (not in US)
a-Interferon
Many types of CMT can be determined by genetic testing. Please consult with a
s
Negligible or doubtful risk:
Allopurinol genetic counselor (www.nsgc.org) or your physician for more information.
Amitriptyline
Chloramphenicol s Although there are no drug treatments for CMT, a healthy diet, moderate exercise,
Chlorprothixene
Cimetidine physical and/or occupational therapy, leg braces or orthopedic surgery may help
Clioquinol
Clofibrate maintain mobility and function.
Cyclosporin A
Enalapril
Glutethimide s The CMTA’s STAR research program and extensive partnerships with pharmaceutical
Lithium companies are driving remarkable progress toward delivering treatments for CMT,
Phenelzine
Propafenone bringing us closer to a world without CMT.
Sulfonamides
Sulfasalazine