Page 24 - 2020 Spring CMTA Report
P. 24

Non-Profit Org.
                                                                                                        U.S. Postage Paid
                                                                                                           Tiffin, OH
                                                                                                          Permit #52
      CMT PATIENT             The Charcot-Marie-Tooth Association
      MEDICATION ALERT:       P.O. Box 105
                              Glenolden, PA 19036
      Definite high risk      1-800-606-CMTA (2682)   FAX (610) 499-9267
      (including asymptomatic CMT):  www.cmtausa.org
      Taxols (paclitaxel, docetaxel,
       cabazitaxel)
      Vinca alkaloids (Vincristine)
      Moderate to significant risk:
      Amiodarone (Cordarone)
      Arsenic Trioxide (Trisenox)
      Bortezomib (Velcade)
      Brentuximab Vedotin (Adcetris)
      Cetuximab (Erbitux)
      Cisplatin and Oxaliplatin
      Colchicine (extended use)
      Dapsone
      Didanosine (ddI, Videx)
      Dichloroacetate
      Disulfiram (Antabuse)
      Eribulin (Halaven)
      Fluoroquinolones
      Gold salts
      Ipilimumab (Yervoy)
      Ixabepilone (Ixempra)
      Lefluonamide (Arava)      W H AT   I S   C M T ?
      Lenalidomide (Revlimid)
      Metronidazole/Misonidazole
       (extended use)
      Nitrofurantoin (Macrodantin,
       Furadantin, Macrobid)
      Nitrous oxide (inhalation abuse)  s  More than 3 million people worldwide have CMT, which is one of the most
      Nivolumab (Opdivo)           commonly inherited nerve disorders and affects the motor and sensory nerves.
      Pembrolizumab (Keytruda)
      Perhexiline (not used in US)
      Pomalidomide (Pomalyst)    s  CMT is slowly progressive, causing the loss of muscle function and/or sensation
      Pyridoxine (mega dose of
       Vitamin B 6)                in the lower legs and feet, as well as hands and arms.
      Stavudine (d4T, Zerit)
      Suramin
      Thalidomide                s  Men and women in all ethnic groups may be affected by CMT.
      Zalcitabine (ddC, Hivid)
                                   CMT is genetic, but it can also develop as a new, spontaneous mutation.
      Uncertain or minor risk:   s
      5-Fluouracil
      Adriamycin                 s  CMT can vary greatly in severity, even within the same family.
      Almitrine (not in US)
      Chloroquine
      Cytarabine (high dose)     s  CMT causes structural deformities such as high-arched or very flat feet, hammertoes,
      Ethambutol
      Etoposide (VP-16)            hand contractures, scoliosis (spinal curvature) and kyphosis (rounded back).
      Gemcitabine
      Griseofulvin                 CMT can also cause foot drop, poor balance, cold extremities, cramps, nerve,
      Hexamethylmelamine         s
      Hydralazine                  muscle and joint pain, altered reflexes, fatigue, tremor, sleep apnea, hearing loss
      Ifosfamide
      Infliximab                   and breathing difficulties.
      Isoniazid (INH)
      Lansoprazole (Prevacid)                         ?
      Mefloquine                 s  CMT rarely affects life expectancy.
      Omeprazole (Prilosec)
      Penicillamine                Some medications are neurotoxic and pose a high risk to people with CMT, notably
      Phenytoin (Dilantin)       s
      Podophyllin resin            Vincristine and Taxols. See full list (at left) of medications that may pose a risk.
      Sertraline (Zoloft)
      Statins
      Tacrolimus (FK506, Prograf)  s  More than 100 different genetic causes of CMT have been identified.
      Zimeldine (not in US)
      a-Interferon
                                   Many types of CMT can be determined by genetic testing. Please consult with a
                                 s
      Negligible or doubtful risk:
      Allopurinol                  genetic counselor (www.nsgc.org) or your physician for more information.
      Amitriptyline
      Chloramphenicol            s  Although there are no drug treatments for CMT, a healthy diet, moderate exercise,
      Chlorprothixene
      Cimetidine                   physical and/or occupational therapy, leg braces or orthopedic surgery may help
      Clioquinol
      Clofibrate                   maintain mobility and function.
      Cyclosporin A
      Enalapril
      Glutethimide               s  The CMTA’s STAR research program and extensive partnerships with pharmaceutical
      Lithium                      companies are driving remarkable progress toward delivering treatments for CMT,
      Phenelzine
      Propafenone                  bringing us closer to a world without CMT.
      Sulfonamides
      Sulfasalazine
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