Page 32 - 2021 Winter CMTA Report

Non-Profit Org.
U.S. Postage Paid
Tiffin, OH
Permit #52
CMT PATIENT
MEDICATION ALERT: The Charcot-Marie-Tooth Association
P.O. Box 105
Definite high risk Glenolden, PA 19036
(including asymptomatic CMT): 1-800-606-CMTA (2682) FAX (610) 499-9267
Taxols (paclitaxel, docetaxel, www.cmtausa.org
cabazitaxel)
Vinca alkaloids (Vincristine)
Moderate to significant risk:
Amiodarone (Cordarone)
Arsenic Trioxide (Trisenox)
Bortezomib (Velcade)
Brentuximab Vedotin (Adcetris)
Cetuximab (Erbitux)
Cisplatin and Oxaliplatin
Colchicine (extended use)
Dapsone
Didanosine (ddI, Videx)
Dichloroacetate
Disulfiram (Antabuse)
Eribulin (Halaven)
Fluoroquinolones
Gold salts
Ipilimumab (Yervoy)
Ixabepilone (Ixempra)
Lefluonamide (Arava)
Lenalidomide (Revlimid) W H AT I S C M T ?
Metronidazole/Misonidazole
(extended use)
Nitrofurantoin (Macrodantin,
Furadantin, Macrobid)
Nitrous oxide (inhalation abuse) s More than 3 million people worldwide have CMT, which is one of the most
Nivolumab (Opdivo)
Pembrolizumab (Keytruda) commonly inherited nerve disorders and affects the motor and sensory nerves.
Perhexiline (not used in US)
Pomalidomide (Pomalyst)
Pyridoxine (mega dose of s CMT is slowly progressive, causing the loss of muscle function and/or sensation
Vitamin B 6)
Stavudine (d4T, Zerit) in the lower legs and feet, as well as hands and arms.
Suramin
Thalidomide Men and women in all ethnic groups may be affected by CMT.
Zalcitabine (ddC, Hivid) s
?
Uncertain or minor risk: s CMT is genetic, but it can also develop as a new, spontaneous mutation.
5-Fluouracil
Adriamycin
Almitrine (not in US) s CMT can vary greatly in severity, even within the same family.
Chloroquine
Cytarabine (high dose)
Ethambutol s CMT causes structural deformities such as high-arched or very flat feet, hammertoes,
Etoposide (VP-16) hand contractures, scoliosis (spinal curvature) and kyphosis (rounded back).
Gemcitabine
Griseofulvin
Hexamethylmelamine s CMT can also cause foot drop, poor balance, cold extremities, cramps, nerve,
Hydralazine
Ifosfamide muscle and joint pain, altered reflexes, fatigue, tremor, sleep apnea, hearing loss and
Infliximab
Isoniazid (INH) breathing difficulties.
Lansoprazole (Prevacid)
Mefloquine CMT rarely affects life expectancy.
Omeprazole (Prilosec) s
Penicillamine
Phenytoin (Dilantin) s Some medications are neurotoxic and pose a high risk to people with CMT, notably
Podophyllin resin
Sertraline (Zoloft) Vincristine and Taxols. See full list (at left) of medications that may pose a risk.
Statins
Tacrolimus (FK506, Prograf)
Zimeldine (not in US) s More than 100 different genetic causes of CMT have been identified.
a-Interferon
Negligible or doubtful risk: s Many types of CMT can be determined by genetic testing. Please consult with a
Allopurinol genetic counselor (www.nsgc.org) or your physician for more information.
Amitriptyline
Chloramphenicol
Chlorprothixene s Although there are no drug treatments for CMT, a healthy diet, moderate exercise,
Cimetidine
Clioquinol physical and/or occupational therapy, leg braces or orthopedic surgery may help
Clofibrate
Cyclosporin A maintain mobility and function.
Enalapril
Glutethimide s The CMTA’s STAR research program and extensive partnerships with
Lithium
Phenelzine pharmaceutical companies are driving remarkable progress toward delivering
Propafenone
Sulfonamides treatments for CMT, bringing us closer to a world without CMT.
Sulfasalazine