Page 28 - 2021 Summer CMTA Report

Non-Profit Org.
U.S. Postage Paid
Tiffin, OH
Permit #52
P.O. Box 105
Glenolden, PA 19036
1-800-606-CMTA (2682)
FAX (610) 499-9267
cmtausa.org

WHAT IS CMT?

CMT PATIENT
MEDICATION ALERT: More than 3 million people worldwide have CMT, which is one of the
most commonly inherited nerve disorders and affects the motor and
Definite high risk Uncertain or sensory nerves.
(including asymptomatic CMT): minor risk:
Taxols (paclitaxel, docetaxel, 5-Fluouracil CMT is slowly progressive, causing the loss of muscle function and/or
cabazitaxel) Adriamycin
Vinca alkaloids (Vincristine) Almitrine (not in US) sensation in the lower legs and feet, as well as hands and arms.
Chloroquine
Moderate to significant risk: Cytarabine (high dose) Men and women in all ethnic groups may be affected by CMT.
Amiodarone (Cordarone) Ethambutol
Arsenic Trioxide (Trisenox) Etoposide (VP-16) CMT is genetic, but it can also develop as a new, spontaneous
Bortezomib (Velcade) Gemcitabine
Brentuximab Vedotin Griseofulvin mutation.
(Adcetris) Hexamethylmelamine
Cetuximab (Erbitux) Hydralazine CMT can vary greatly in severity, even within the same family.
Cisplatin and Oxaliplatin Ifosfamide
Colchicine (extended use) Infliximab CMT causes structural deformities such as high-arched or very flat
Dapsone Isoniazid (INH) feet, hammertoes, hand contractures, scoliosis (spinal curvature) and
Didanosine (ddI, Videx) Lansoprazole (Prevacid)
Mefloquine
Dichloroacetate Omeprazole (Prilosec) kyphosis (rounded back).
Disulfiram (Antabuse) Penicillamine
Eribulin (Halaven) Phenytoin (Dilantin) CMT can also cause foot drop, poor balance, cold extremities, cramps,
Fluoroquinolones Podophyllin resin nerve, muscle and joint pain, altered reflexes, fatigue, tremor, sleep
Gold salts Sertraline (Zoloft) apnea, hearing loss and breathing difficulties.
Ipilimumab (Yervoy) Statins
Ixabepilone (Ixempra) Tacrolimus CMT rarely affects life expectancy.
(FK506, Prograf)
Lefluonamide (Arava) Zimeldine (not in US)
Lenalidomide (Revlimid) a-Interferon Some medications are neurotoxic and pose a high risk to people with
Metronidazole/Misonidazole Negligible or
(extended use) CMT, notably Vincristine and Taxols. See full list (at left) of medications
Nitrofurantoin doubtful risk: that may pose a risk.
(Macrodantin, Furadantin, Allopurinol
Macrobid) Amitriptyline
Nitrous oxide Chloramphenicol More than 100 different genetic causes of CMT have been identified.
(inhalation abuse) Chlorprothixene
Nivolumab (Opdivo) Cimetidine Many types of CMT can be determined by genetic testing.
Pembrolizumab (Keytruda) Clioquinol Please consult with a genetic counselor (www.nsgc.org) or your
Perhexiline (not used in US) Clofibrate
Pomalidomide (Pomalyst) Cyclosporin A physician for more information.
Enalapril
Pyridoxine (mega dose Glutethimide
of Vitamin B 6) Although there are no drug treatments for CMT, a healthy diet,
Stavudine (d4T, Zerit) Lithium moderate exercise, physical and/or occupational therapy, leg braces
Phenelzine
Suramin Propafenone
Thalidomide Sulfonamides or orthopedic surgery may help maintain mobility and function.
Zalcitabine (ddC, Hivid) Sulfasalazine
The CMTA-STAR research program and extensive
The medications listed above are potentially toxic to CMT patients. partnerships with pharmaceutical companies are driving
Vincristine has been proven hazardous and should be avoided by all
CMT patients, including those with no symptoms. Taxols also pose a remarkable progress toward delivering treatments for
high risk to people with CMT. The remainder of the medications listed
above present varying degrees of potential risk for worsening CMT CMT, bringing us closer to a world without CMT.
neuropathy. Before taking any medication or changing medication,
all CMT patients should make sure the treating physician is fully
aware of their medical condition.